| Date | GMT | Match Details | Venue |
| Sep 10, 2010 | 15:30 | Mumbai Indians vs Highveld Lions , 1st T20 Match | The Wanderers Stadium, Johannesburg |
| Sep 11, 2010 | 11:30 | Warriors vs Wayamba , 2nd T20 Match | St Georges Park, Port Elizabeth |
| Sep 11, 2010 | 15:30 | Central Stags vs Chennai Super Kings , 3rd T20 Match | Kingsmead, Durban |
| Sep 12, 2010 | 11:30 | Highveld Lions vs South Australian Redbacks , 4th T20 Match | SuperSport Park, Centurion |
| Sep 12, 2010 | 15:30 | Bangalore Royal Challengers vs Guyana , 5th T20 Match | SuperSport Park, Centurion |
| Sep 13, 2010 | 15:30 | Victoria vs Warriors , 6th T20 Match | St Georges Park, Port Elizabeth |
| Sep 14, 2010 | 15:30 | Mumbai Indians vs South Australian Redbacks , 7th T20 Match | Kingsmead, Durban |
| Sep 15, 2010 | 11:30 | Central Stags vs Wayamba , 8th T20 Match | SuperSport Park, Centurion |
| Sep 15, 2010 | 15:30 | Chennai Super Kings vs Wayamba , 9th T20 Match | SuperSport Park, Centurion |
| Sep 16, 2010 | 15:30 | Mumbai Indians vs Guyana , 10th T20 Match | Kingsmead, Durban |
| Sep 17, 2010 | 15:30 | Bangalore Royal Challengers vs South Australian Redbacks , 11th T20 Match | Kingsmead, Durban |
| Sep 18, 2010 | 11:30 | Central Stags vs Warriors , 12th T20 Match | St Georges Park, Port Elizabeth |
| Sep 18, 2010 | 15:30 | Chennai Super Kings vs Victoria , 13th T20 Match | St Georges Park, Port Elizabeth |
| Sep 19, 2010 | 11:30 | Highveld Lions vs Guyana , 14th T20 Match | The Wanderers Stadium, Johannesburg |
| Sep 19, 2010 | 15:30 | Mumbai Indians vs Bangalore Royal Challengers , 15th T20 Match | Kingsmead, Durban |
| Sep 20, 2010 | 15:30 | Victoria vs Wayamba , 16th T20 Match | SuperSport Park, Centurion |
| Sep 21, 2010 | 11:30 | South Australian Redbacks vs Guyana , 17th T20 Match | The Wanderers Stadium, Johannesburg |
| Sep 21, 2010 | 15:30 | Highveld Lions vs Bangalore Royal Challengers , 18th T20 Match | The Wanderers Stadium, Johannesburg |
| Sep 22, 2010 | 11:30 | Central Stags vs Wayamba , 19th T20 Match | St Georges Park, Port Elizabeth |
| Sep 22, 2010 | 15:30 | Chennai Super Kings vs Warriors , 20th T20 Match | St Georges Park, Port Elizabeth |
| Sep 24, 2010 | 15:30 | TBC vs TBC , 1st Semi Final T20 Match | Kingsmead, Durban |
| Sep 25, 2010 | 15:30 | TBC vs TBC , 2nd Semi Final T20 Match | SuperSport Park, Centurion |
| Sep 26, 2010 | 15:30 | TBC vs TBC , Final T20 Match | The Wanderers Stadium, Johannesburg |
